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The Arctic HYDRA Research Facility was one of HYDRA's research facilities, specifically designed to research on enhanced people. The facility was commanded by Dr. List, the right hand man of Baron Wolfgang von Strucker.
Ethan Johnston was captured by HYDRA and brought to the facility for experimentation. He later died in the experiment's 37th hour. List was frustrated with the experiments, because they had not discovered any quantum entanglements in Johnston's DNA.
Agent Phil Coulson and his team infiltrated the base by sacrificing the Bus to HYDRA's missile defense system while cloaking their Quinjet. The team later proceeded to rescue Peterson and Lincoln from HYDRA and disable HYDRA's anti-aircraft missile defenses, allowing the S.H.I.E.L.D. jets to destroy the base.
While Coulson's Team were fulfilling their orders, Coulson secretly extracted intelligence regarding Loki's Scepter. Coulson later reported his findings to Maria Hill; she then inquired if Theta Protocol was ready.