For other uses, see Centipede (disambiguation)
"It's the only thing that's been keeping me alive these past few months."
John Garrett[src]

The Centipede Serum is a chemical compound created by Raina with help from other Centipede scientists under the order of John Garrett, using the alias "The Clairvoyant" to cover his identity. It gives its users enhanced strength and invulnerability. It is the source of the powers for the Centipede Soldiers.



Desiring a way to keep himself alive, John Garrett ordered the creation of the serum. To this end, he developed Project Centipede. Raina, a talented scientist involved in the Project, combined various sources that were known to create superpowers or give unearthly attributes and created a version of the serum.


This version was proved to be highly unstable during testing. As part of this test, Raina recruited Mike Peterson and a second subject to the program and Debbie and another scientist injected the men with the serum via an intravenous filter.


Mike Peterson's filter

By using Extremis to create the serum, it caused the users to become unstable and explode after a certain period of time. This occurred resulting in the deaths of the other doctor and the second subject as well as the destruction of the Project's lab in Los Angeles. The explosion exposed the project and brought it to the attention of S.H.I.E.L.D. This nearly happened with Peterson but he was prevented from exploding by being injected with dendrotoxin by Coulson's Team.[1]

Hong Kong

Centipede Serum

Chan Ho Yin injecting himself the serum at the Centipede Project warehouse in Hong Kong

Having relocated to Hong Kong, the project sought out another subject with whom they hoped to stabilize the serum. Raina brought it in Chan Ho Yin, a pyrokinetic on S.H.I.E.L.D.'s Index. They discovered that because of Chan's abnormal blood platelets, he could not explode. Debbie then removed the platelets from Chan who was starting to become mentally unstable. Raina and Debbie attempted to flee the facility but only Raina escaped; Debbie was killed by Chan.[2]

Expanded Use

John Garrett injected himself with the serum but, due to his deteriorating condition, it only kept him alive and did not give him enhanced abilities. Garrett then ordered Raina to create an army of Centipede Soldiers. These soldiers were successful but also required enormous amounts of energy and rest which they did not receive because the Project could not stay in any location for long due to S.H.I.E.L.D. surveillance. These soldiers were stopped by Coulson's Team and Raina was arrested by S.H.I.E.L.D., but the Project gained control of Mike Peterson and implanted him with their Backscatter X-Ray Eye Implant.[3]

HYDRA Uprising


Deathlok Super Soldiers in Cuba

HYDRA was revealed to have infiltrated S.H.I.E.L.D., and Garrett was exposed. He managed to escape imprisonment with the help of fellow infiltrator Grant Ward.[4] Ward then freed Raina[5] who continued her work with the serum using HYDRA's incentives program to acquire more subjects whom she turned into Centipede Soldiers.[6]

Raina found and recreated the GH.325 to complete the serum for John Garrett by doing research on Coulson's Team Hard Drive.[7]

At the Battle at Cybertek, these subjects were freed from HYDRA's control.[6]



"I'm reading alien metal, gamma radiation, the serum... every known source of superpower thrown in a blender."
Jemma Simmons[src]

The first version of the serum gave the user superhuman strength, speed, durability, and a regenerative healing factor. This version of the centipede serum was highly unstable due to Extremis.

The second version which included Chan Ho Yin's blood platelets stabilized the serum allowing the users to stop exploding and use the serum properly.

The third version which included the GH.325 allowed those users such as John Garrett that were severely injured to gain the abilities a normal Centipede Soldier would have. The side effect was that the user would then slowly go crazy and start carving the Words of Creation.


Appearances for Centipede Serum


Centipede Serum GH 325

Adding GH.325 to the serum

The normal color of the serum is bright orange, but when Raina added the recreated GH.325, the serum became blue.[7]