- Cobie Smulders was recommended for the part of Maria Hill by Alyson Hannigan, her co-star in How I Met Your Mother, a frequent collaborator of Joss Whedon and wife of Alexis Denisof, who Cobie Smulders had also previously worked with in How I Met Your Mother.
- Whedon also considered her for the role of Wonder Woman in his cancelled film project. She later voiced the character in The Lego Movie.
- Cobie Smulders Wen voiced an alternate version of Maria Hill in Lego Marvel's Avengers.
- Cobie Smulders also portrayed Shannon Bell in the comic book adaptation Smallville.