Destroyer may refer to:
- Destroyer - The Destroyer was an enchanted, automated Asgardian weapon used, primarily, to guard the Weapon's Vault of Asgard.
- Destroyer Armor Prototype Gun - The Destroyer Armor Prototype Gun is a weapon made out of the Destroyer's body and designed by a group of S.H.I.E.L.D. scientists.
- Drax the Destroyer - Drax, also known as Drax the Destroyer, is a former intergalactic criminal and a member of the Guardians of the Galaxy.
- Quake - In the future of 2091, Daisy Johnson was known as the Destroyer of Worlds due to the belif that she was responsible for destroying the Earth.