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Holden Radcliffe

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"I believe that art and science are entwined. The Devil, and God, is in the details. I don't want the people to see my work and know it works. If they gave a second glance, I want it to be out of awe, not disgust."
―Holden Radcliffe to Jemma Simmons[src]

Holden Radcliffe is a former GT Agrochemical researcher whose theories and experiments on transhumanism got him fired from the company. He was kidnapped and recruited by Hive in order to recreate the Kree experiment which had created the Inhumans. However despite Radcliffe's enthusiasm, he struggled to perfect the experiment, inadvertently creating the Primitives. He was saved by S.H.I.E.L.D. and assisted them in defeating Hive.

Radcliffe reached a deal where he was eventually cleared of all charges, but with the condition that all of his research were submitted to approval and oversight. However, despite becoming friends with Leo Fitz and Jemma Simmons, Radcliffe secretly began working on Life-Model Decoys.


Early Life

"He was lead researcher on parasitic organisms at the agrochemical lab we raided, based on his expertise we believe he is the key to finding a cure for Daisy."
Jemma Simmons[src]

Radcliffe's S.H.I.E.L.D. file

Doctor Holden Radcliffe was a highly successful scientist at GT Agrochemical, however he was dismissed from the company when his complete obsession with Transhumanism were deemed to be inhumane. Shortly after his dismissal, Radcliffe's old lab was attacked and destroyed by HYDRA, with all his former co-workers being killed. Radcliffe went to Romania to hide out and continue his research among others who shared his passion for Transhumanism.[1]

Learning of Inhumans

Holden Radcliffe Singularity 5

Radcliffe meets Jemma Simmons

"I see how it's surveillance capabilities are appealing, but there was a company that had something eerily similar, Cybertek, heard of them? Turns out they were HYDRA. They connected explosives to soldiers eyes, violence for violence sake, an ugly misuse of science."
―Holden Radcliffe to Jemma Simmons[src]

While hiding out in Romania, Radcliffe was informed by Anon that two scientists were looking to sell technology to him. In order to test if Leo Fitz and Jemma Simmons were truly confident in their Transhuman product, Radcliffe strapped himself on a operation table and ordered Anon to retrieve the two scientists and tell them to replace his false eye with their technology, not telling them that the eye was not real. When Simmons went to apply the anesthetic to his eye, she realized that the eye was not real. Radcliffe then revealed himself to the pair.

Holden Radcliffe Singularity 16

Radcliffe questions Leo Fitz's motives

Radcliffe went on to question the two about the Eye Implant, noting that while he was impressed by its technology, he knew that Cybertek had similar technology and they had been revealed to be connected to HYDRA. Simmons assured that they did not work for HYDRA but S.H.I.E.L.D., yet Radcliffe dismissed the comment, saying that the two organizations are the same. Eventually Radcliffe realized that Fitz was in communication with someone and ordered Anon to activate an EMP before calling security and escort the pair out.

Holden Radcliffe Singularity 17

Radcliffe argues with Leo Fitz about Inhumans

As Fitz and Simmons pleaded with Radcliffe to reconsider, Simmons was taken away by his men before Fitz was able to fight them off and told Radcliffe that he had to hear him out. Fitz revealed that there was a creature called Hive that was recruiting Inhumans and they needed his help to stop it, promising he could help Radcliffe discover the truth. Suddenly the lab's doors suddenly burst open and Daisy Johnson and Alisha Whitley stormed in. Whitley took away the startled doctor, while Johnson attacked Anon and threatened Fitz.[1]

Kidnapped by Hive

Holden Radcliffe Singularity 23

Radcliffe is kidnapped and questioned by Hive

"We've only just begun that kind of DNA modification, to make something of your kind that's... We can only dream."
"You don't need to dream anymore."
―Holden Radcliffe and Hive[src]

Radcliffe was taken away to Union City where he was introduced to Hive, and was astonished to be surrounded by the Inhumans. Hive then offered Radcliffe the chance to initiate an experiment that originally created Hive, noting that the technology of the humans now matched that of the Kree and Radcliffe was the best candidate for the job. Although Radcliffe was uncertain that the task could be done, Hive assured him that it would be in his best interest to try and succeed.[1]

Failed Experiments

Failed Experiments 3

Radcliffe recreates the Kree experiment

"The genetic make up of Inhumans in incredibly complex, we were bound to run into complications!"
"You assured me this would work."
"Yes, it would have if I'd been provided with the right ingredients."
―Holden Radcliffe and Hive[src]

Hive provided Radcliffe with three volunteers from HYDRA once his experiment was ready, with Radcliffe explaining to Hive and Daisy Johnson that he had managed to put Terrigen Crystals into the Kree blood to ensure that the subjects underwent Terrigenesis at the same time. However as soon as the experiment went underway, Kirk Vogel and the other volunteers began screaming in agony before they skin and bones melted away into slim as their bodies reacted to the experiment.

Failed Experiments 5

Radcliffe's life is threatened by Hive

As the corpses of the volunteers were taken away to be disposed of, Radcliffe desperately tried to explain to Hive that the experiment had only failed because the blood he had been supplied with had come from the dead body of Grant Ward and they needing the blood of a living Kree. Hive responded by grabbing Radcliffe by the throat as he begged for his life, promising that he could make the experiment work as he promised that he wanted it to work in order to change the world. Hive let Radcliffe go before walking over to the Kree Orb, when Radcliffe asked what it was, Hive did not answer but explained that Radcliffe should be terrified now.[2]

Encounter with the Kree


Radcliffe is attacked by a Kree Reaper

"You were going to handle this thing! Now we're both gonna die!"
"No ones dying here today!"
―Holden Radcliffe and Daisy Johnson[src]

Hive used the Kree Orb to summon the Kree Reapers to Union City so Radcliffe could use their blood to complete his experiment. While in his lab, Radcliffe was confronted by one of the Reapers whose blade was covered in Alisha Whitley's blood. Radcliffe was defended by Daisy Johnson who battled the powerful Kree warrior while Radcliffe looked on in fear, eventually Johnson was able to outwit the Kree and broke it's spine.


Radcliffe begins draining the Kree's blood

Radcliffe was ordered to drain the Kree's blood, but as he was doing this, he and Johnson were confronted by Alphonso Mackenzie who had come to convince Johnson to return to S.H.I.E.L.D.. Radcliffe continued his work until Mackenzie used a Splinter Bomb to destroy the Kree's body, leading to Johnson attacking her former ally and friend. Mackenzie was rescued by his team mates who escaped in the Containment Module. Radcliffe patched up Johnson's wounds before she revealed to Hive that she had Kree blood in her veins.[2]

Creating Abominations


Radcliffe checks on Daisy Johnson's recovery

"These Primitives are an Abomination of science and a very poor reflection of my talents."
"They are not abominations, they're part of me and the Inhuman race. I want you to make more"
―Holden Radcliffe and Hive[src]

Radcliffe checked on Daisy Johnson as she continued to give up her Kree blood for their experiments, ensuring that she was recovering and staying as healthy as possible while Radcliffe advised her to stop for the day. Radcliffe told Johnson to drink juice to recover but was so tired that he almost gave her her own blood back, claiming that he would rest once he was dead, although insisting that he did not want any of them to die.


Radcliffe discusses his experiments with Hive

Leaving Johnson to continue her recovery, Radcliffe took Hive into his lab and informed him that he was now confident that the experiment would work as he now had the right ingredients compared to the last test where he had killed Kirk Vogel. Radcliffe assured Hive that everything was in place to complete their experiment and create new Inhumans and all they needed at this stage was new volunteers, which Hive assured him that he was sourcing already, claiming that his choice of volunteers he considered to be a gift for Johnson.

Failed Experiments 10

Radcliffe sees the arrival of the Watchdogs

When the volunteers Hive had spoken about earlier finally arrived, Radcliffe was horrified to learn that they were kidnapped members of the Watchdogs; when Radcliffe questioned Hive about this he explained that they sometimes needed more motivation while Hellfire beat Pete Boggs with the butt of his gun while mocking him. Once he confirmed that he was almost completely confident about the experiment, Hive ordered Radcliffe to fill the shipment container the Watchdogs were in with Terrigen Mist. Radcliffe and the others then listened as the men screamed in fear and pain as they underwent their forced Terrigenesis.


Radcliffe is horrified by creating the Primitives

Eventually the doors to the container were opened, revealing the men had mutated into hideous Primitives, horrifying Radcliffe. Hive however was impressed by the result and ordered the Primitives to show off their strength and bring Radcliffe to him on his knees. Radcliffe begged for his life as he insisted that he could improve upon the experiment, although Hive claimed that they would do fine while Radcliffe argued that the Primitives were abominations to science while Hive insisted that he wanted Radcliffe to create more.


Radcliffe witnesses Lash attacking Hive

As Radcliffe was ordered to drain Johnson on the last of her blood, he witnessed Lash arriving on the base and attacking Hive, leading to the exhausted Johnson getting up to try and defend her leader. As Lash went to kill Hive, Radcliffe explained that Hellfire had left to collect beer and watched helplessly as Johnson tried in vain to stop Lash with a weak shockwave before collapsing. Radcliffe then escaped the base before witnessing Lash saving Johnson from Hive's mind control before being killed by Hellfire.[3]

Saved by S.H.I.E.L.D.


Radcliffe watches Hive's plans unfold

"Did S.H.I.E.L.D. send you?! Did they?!"
"Yes, I'm with S.H.I.E.L.D.!"
"Oh thank god, take me with you, you have to, please!"
―Holden Radcliffe and Melinda May[src]

To be added

This section requires expansion

Attack of the Primitives

"Crank the heating up to a hundred degrees Fahrenheit and we're free to move about as we please."
"You so want us to go out there on a hunch and hope those things don't rip us apart?"
"It's not a hunch, it's science. It's a science hunch."
―Holden Radcliffe and Alphonso Mackenzie[src]

To be added

This section requires expansion

Creating Life-Model Decoys

Third Season Finale 8

Radcliffe prepares to create L.M.D.s

"This is based on an old S.H.I.E.L.D. program, poor kids have had a lot of friends die, maybe they didn't have to."
"Is that what we're celebrating today? The inclusion of your new colleague Fitz on this project?"
"No Aida, today, today's your birthday."
―Holden Radcliffe and Aida[src]

With Hive having been killed by S.H.I.E.L.D., Radcliffe returned to his research, working alongside Leo Fitz and Jemma Simmons a lot, gaining a deep affection for the pair. Eventually all charges against Radcliffe regarding the creation of the Primitives were dropped and Radcliffe returned to his office and spoke to Aida, explaining that his time with Fitz and Simmons had given him the idea to finally create Life-Model Decoys in order to protect them from losing more friends during their fights to protect the world from danger.[4]

Pitching Aida

To be added

Killing Melinda May

To be added

Work with the Darkhold

"Look, if the internet is a garden hose, this book is Niagara Falls, blasting the universe's deepest thoughts through your eyeballs."
"It's a piece of technology, a tool."
"So's a grenade, until it's in the hands of a child."
―Holden Radcliffe and Melinda May[src]

To be added


To be added

Powers and Abilities


"Bird's visual acuity is superior to mammals; I got envious."
―Holden Radcliffe[src]
  • Enhanced Sight: Radcliffe replaced his right eye with a synthetic prosthesis based on a bird's, granting him enhanced vision, as part of his beliefs in applying science to follow the discipline of transhumanism.


This section requires expansion
  • Master Scientist: To be added


This section requires expansion
  • Smith & Wesson M&P: When S.H.I.E.L.D. agent Melinda May burst into the maintenance room of the silo where Radcliffe was held, she dropped this pistol after attempting to eliminate some Primitives. In self-defense, Radcliffe picked up the pistol and saved May by firing at a Primitive that was about to kill her.





Appearances for Holden Radcliffe

In chronological order:


  • In the comics, Holden Radcliffe was the founder and owner of the Holden Radcliffe Corporation, obsessed with developing androids as combat soldiers.


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