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He portrayed himself in Agents of S.H.I.E.L.D.: Academy.
- He was named TVLine's "Performer of the Week" for his acting in the episode Laws of Nature.
- Leo Fitz's obsession with monkeys was inspired by Iain De Caestecker's own love for monkeys.
- Iain De Caestecker voiced an alternate version of Leo Fitz in Ultimate Spider-Man.