Lisbon is the largest city and capital of Portugal.
Victoria Hand and John Garrett were stationed together in Lisbon during their careers as S.H.I.E.L.D. agents, getting to know each other, with Garrett feeling emboldened enough to start calling her "Vic", even though she despised that nickname.
Garrett acknowledged that Hand was a spoilsport and an authoritative person; thus, at first, he found hard to believe Phil Coulson's conclusion that Hand was the actual identity of the Clairvoyant.
In 2015, Werner von Strucker, son of former HYDRA leader Wolfgang von Strucker went into hiding to avoid being punished by Grant Ward, the leader at the time. Eventually, he was found and tortured by Ward's subordinate Kebo and several HYDRA thugs. However, S.H.I.E.L.D. agents Melinda May and Bobbi Morse arrived at the scene and a battle took place. Ultimately, Kebo was killed by Morse and Werner went into a coma after suffering numerous wounds.