Man-Thing was one of the many individuals monitored by S.H.I.E.L.D.
Man-Thing was among the many creatures being observed by S.H.I.E.L.D.
During the HYDRA Uprising, S.H.I.E.L.D. was dissolved and all of its files were publicized, including those regarding the Man-Thing and its background. It was briefly mentioned during a conversation between Pepper Potts and former S.H.I.E.L.D. Deputy Director Maria Hill as she was leaving a Congressional hearing. Hill was giving Potts a list of the questions asked her and one was pertaining to Man-Thing.
- In the comics, Ted Sallis, the alter-ego of the Man-Thing, was a biochemistry professor at Empire State University who was married to Ellen Brandt, scarring her face after she betrayed him to A.I.M..