- "Peter, I know these last few months have been hard for you. But I’m going to a better place and I will be okay. And I will always be with you. You are the light of my life. My precious son. My little Star-Lord. Love, Mom."
- ―Meredith Quill to Star-Lord
Meredith was born and raised in St. Charles, Missouri. Growing up, she developed a strong love for pop music, with Ego claiming that she memorized every song that came over the radio. She eventually met Ego with whom she fell in love. At some point in 1980, Ego drove her out to a forest where he showed her a seedling he had planted, claiming that it would soon spread everywhere across the planet. Later that year, Meredith was impregnated by Ego and gave birth to a son who, she named Peter. Ego was soon forced to return to his planet, in order to replenish his life force. Meredith raised Peter by herself and gave him a Walkman with a mix tape of her favorite songs, which Peter adamantly protected from then on. She called him her little "Star-Lord", which an adult Peter adopted as his outlaw name.
Ego returned three times to visit Meredith. Fearing that he was becoming too attached to her and becoming unfocused in his mission, Ego inserted a tumor into her head, causing her to slowly die of brain cancer.
Meredith died of terminal cancer in 1988, when Peter was eight years old, but gave him a second mix tape of music just before passing. He did not open this second tape until many years later, after defending the planet Xandar as a member of the Guardians of the Galaxy. After taking hold of the Power Stone during the conclusion of the battle to prevent Ronan the Accuser from taking it back, Peter's body begins to rip apart, causing him unbearable pain. He begins hallucinating and sees an image of his dying mother asking him to take his hand. In reality, this is Gamora calling to him to take her hand so that they can share and absorb the stone's power.
- Ego † - Former Lover and Killer
- In the comics, Meredith rescued the space prince J'son and fell in love with him. After his departure, she was killed by two Badoon soldiers, who were enemies of J'son and sent to kill their son Peter.