Midtown High School of Science & Technology was established in 1962.
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- In the comics, Peter Parker and Jessica Jones were classmates in Midtown High. Jones also had a crush on Peter.
- Midtown School of Science & Technology was established in 1962, as a reference to Spider-Man's first appearance in the comics.
- Howard Stark and Abraham Erskine appear in a mural in the school and Bruce Banner is among the famous scientists pictured in one of the classrooms.