- Peter MacNicol is one of the few actors to portray characters for both Marvel Studios and DC Entertainment. He voiced Chronos in Justice League Unlimited, Man-Bat in The Batman, Professor Ivo in Young Justice and Mad Hatter in Batman: Arkham City, Batman: Arkham Origins and Batman: Arkham Knight.
- Peter MacNicol is one of the few actors to portray characters for both Marvel Studios and Lucasfilm, both of which are owned by Walt Disney Pictures. He voiced Tseebo in Star Wars Rebels.
- Peter MacNicol also voiced Doctor Octopus in The Spectacular Spider-Man
- He is known portraying David Langley in a Mr. Bean movie, Bean.