Powers Boothe portrayed Gideon Malick in The Avengers and the Agents of S.H.I.E.L.D. episodes Among Us Hide..., Chaos Theory, Many Heads, One Tale, Closure, Maveth, Bouncing Back, The Inside Man, Parting Shot, Spacetime, Paradise Lost and The Team.
- Powers Boothe also portrayed Senator Roark in the comic book film adaptations Sin City and Sin City: A Dame to Kill For.
- Powers Boothe is one of the many actors to portray characters for both Marvel and DC Entertainment. He portrayed Gorilla Grodd in Justice League and Justice League Unlimited and Lex Luthor in Superman: Brainiac Attacks.