- Sam Rockwell was considered for the role of Tony Stark in Iron Man.
- Sam Rockwell previously worked with Jon Favreau in Made, G-Force and subsequently on Cowboys & Aliens. Cowboys & Aliens is a comic book adaptation in which Sam Rockwell portrayed Doc.
- Sam Rockwell has been in a relationship with Leslie Bibb since 2007. He previously worked with her in Don Verdean.
- Sam Rockwell also portrayed Head Thug in the comic book adaptation Teenage Mutant Ninja Turtles.
- Sam Rockwell previously worked with Clark Gregg in Choke and again in Trust Me, both of which Gregg also directed.
- Sam Rockwell worked again with Justin Theroux in Mute.