|For Thanos' warship, see Sanctuary II|
When Loki fell from Asgard and into Yggdrasil, he was transported to the Sanctuary. There, he was captured and tortured by the Other in order to ensure his compliance and submission; he was also trained by Thanos in the ways of mind control.
After Gamora's betrayal, a furious Ronan the Accuser traveled to Sanctuary where he met with Thanos in person and angrily berated him for not taking Gamora's betrayal seriously. When The Other, Thanos' servant, scolded Ronan for disrespecting the warlord, Ronan angrily broke the Other's neck, killing him and forcing Thanos to speak to Ronan directly. Undaunted by Ronan's complaints, Thanos waved the Kree away, and while Gamora's betrayal was an issue, Thanos entrusted both Ronan and Nebula with fixing that problem. As Ronan departed, Thanos grimly warned him that if he returned empty handed again, he would "bathe the starways" in his blood.
- In the comics, the "Sanctuary", and its two duplicates, served as Thanos' space ark and base of operations in his plan of stellar genocide in an attempt to court Death. However, his plans were thwarted by the spirit of Adam Warlock, who turned the Titan into stone aboard one of Thanos' Sanctuary starships.
- The coordinates for the Sanctuary are N5X2 1O6311411+2123518.
- Tony Stark's vision caused by Scarlet Witch during the Attack on the HYDRA Research Base made him see his fellow Avengers dead on the landscape of Sanctuary.