The Sanctum Sanctorum in New York City is one of the three bases of the Masters of the Mystic Arts alongside the London Sanctum and the Hong Kong Sanctum. It is used to store and secure mystic items such as the Dark Scepter and the Cloak of Levitation.
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Retrieving the Dark Scepter
As the Zealots attacked the London Sanctum, Stephen Strange was thrown into the Sanctum Sanctorum through its portal on Kamar-Taj. He witnessed the Zealots killing Drumm before taking them on. During the fight, Strange used the Rotunda of Gateways to trap the Zealots across Earth. As Strange and Kaecilius fought, one of the relics stored there, the Cloak of Levitation, was released and started to defend Strange. Strange immobilized the Zealot leader Kaecilius with the Crimson Bands of Cyttorak and, as he talked to him, he was attacked and stabbed by Lucian with a Space Shard. As the Cloak pinned the Zealot behind, Strange created a portal to Metro-General Hospital seeking the help of Christine Palmer.
Once Strange returned, he found Karl Mordo and the Ancient One assessing the damages, with Kaecilius already gone. The Ancient One invited Strange to become the new Master to replace the now deceased Daniel Drumm, but he refused the offer. Later, Kaecilius and the Zealots returned to the Sanctum and prepared to destroy the New York Sanctum. Mordo leapt to fight the Zealots but, before they could destroy the building, Strange dragged them all into the Mirror Dimension to isolate them from the Physical World. Kaecilius began manipulating the Mirror Dimension and gave chase to Strange and Mordo outside the Sanctum and throughout New York City.
After Doctor Strange had defeated Kaecilius and the Zealots in Hong Kong, Strange accepted his duty and moved into the Sanctum Sanctorum.
Meeting with ThorSeveral months into his time as the Sanctum Sanctorum's guardian, Doctor Strange received a visit from Thor, to discuss why Thor brought Loki to Earth once more.
- In the comics, the Sanctum has served as the base for both the Defenders and the New Avengers.
- "Sanctum sanctorum" is a Latin translation of the biblical term "Holy of Holies".
- The Sanctum Sanctorum is one of various landmarks featured in the non-canon video game The Incredible Hulk.
- The room in which the relics are kept is the Chamber of Relics.
- The room in which there are doorways to other parts of the world is the Rotunda of Gateways. The doors are used to spread the sorcerers' influence around the world.