Toshiro Mori, a Japanese engineer with ties to HYDRA, received schematics from Daniel Whitehall and Skye's Father modifying the prototype and incorporating the power of the Diviner. After its creation, all of the Splinter Bombs Mori made were exported to be used by Marcus Scarlotti. 
The opening salvo was when Italian representative Adamo Dioli was hit in his chest with a bomb while he was responding to Glenn Talbot's speech. As the others in the room were struck with surprise and fear, Dioli disintegrated.
When a security guard responded to the invasion of HYDRA agents led by Marcus Scarlotti, he was hit with a bomb and killed.
As Talbot was ushering people from the meeting room, Scarlotti threw a Splinter Bomb at him. Talbot escaped with a broken arm, though six died in the attack.
Scarlotti then used the Splinter Bomb to personally kill Noelle Walters by stabbing her with the device and letting it burrow into her.
Splinter Bomb Decoy
In his search to understand the Monolith, Leo Fitz created a case full of modified Splinter Bombs that gave off a flashbang effect, which he traded to a group of Moroccan gangsters in exchange for a scroll pertaining to the Monolith. When the gangsters turned on him and attempted to use a Splinter Bomb on him, it let out a large flash that enabled Fitz to flee with his prize.
Destroying an Experiment
In Union City, Holden Radcliffe tried to use some of the Kree Reapers's blood for the Absolution Virus. However, Alphonso Mackenzie entered the warehouse and used a Splinter Bomb to destroy the Kree's body.
Leo Fitz hid some S.H.I.E.L.D. equipment in the Lighthouse so the rest of the them would use it in the year 2091. Among the items were the Splinter Bombs. In an alternate timeline, when Alphonso Mackenzie, Yo-Yo Rodriguez and Flint found the hidden box to fight the Vrellnexians who were attacking the Lighthouse residents, Rodriguez armed herself with the Splinter Bomb. She used her powers to plant the bombs on the creatures in mid air and they were disintegrated.
As the bomb burrows into the body of its target, the bomb releases a substance that replicates the petrifying power of the Diviner. The subject begins to disintegrate after a few seconds, quickly crumbling into mere atoms.
The bombs have a disc-like shape with symbols that glow one at a time when thrown, suggesting a timer or activation mechanism.
in chronological order:
- Agents of S.H.I.E.L.D.
In an alternate timeline: