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During the HYDRA Uprising, Susanna, alongside with Alphonso Mackenzie, Case and Tim Maguire were captured by HYDRA. She witnessed how the leader of the assault killed Maguire. He then grabbed Susanna, threatening to kill her if Mackenzie did not cooperate with him. She and the two others were saved by Bobbi Morse and Isabelle Hartley who managed to kill the HYDRA agents. Hartley handed her a gun to defend herself before they traversed the ship.
The five agents searched for Robert Gonzales and after they found him, Susanna helped him to recover from his broken leg. Morse revealed that she was given a secret mission by Nick Fury to destroy the ship before HYDRA could get their hands on its cargo. Gonzales tried to persuade her to continue the mission but she listened to Mackenzie instead, who said to her to ignore Fury's order and claim back the ship; Susanna agreed with Mackenzie, voicing that he was right. Susanna fought with the other agents against the rest of HYDRA on the ship and helped to reclaim it.
- S.H.I.E.L.D. (First Incarnation)